Scientific program

TACKLING FUTURE CHALLENGES IN BIOSEPARATION

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PROGRAM



Day 1 Monday, February 18
13:30 Opening Remarks - Shigeru Nakatani and Alois Jungbauer
13:45 Opening Keynote - Chairman: Alois Jungbauer
Complex biopharmaceuticals drive implementation of novel and smart technologies
Roman Necina, Shire, Austria
  Session 1 - Mechanisms of protein/biomolecule - surface interaction -
Chairman: Alois Jungbauer
14:45 An Affinity Complex Titration Isotherm for Protein A Chromatography: Implications for Competitive Antibody Binding Behavior
Todd Przybycien, Rensselaer Polytechnic Institute, United States
15:15 Computational fluid dynamics to understand protein chromatography form nanoscale to macro scale
Alois Jungbauer, BOKU, Austria
15:45 3D model of antibody adsorption on TOYOPEARL AF-rProtein A HC and Mabselect SuRe
Silva Goncalo, BOKU, Austria
16:15 Coffee break
16:45 A calorimetric perspective on the mechanism of interaction between biomolecules and salt-tolerant ion exchangers
Ana Cristina Dias-Cabral, University of Beira Interior, Portugal
17:15 Exploiting the U-shaped Dependencies of Biomolecule Retention on Mobile Phase Composition in Isocratic and Gradient Elution Separations with Different Types of Chromatographic Adsorbents
Milton Hearn, School of Chemistry, Monash University, Australia
18:30 Dinner

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Day 2 - Tuesday, February 19
8:30 Keynote - Chairman: Alexander Faude
Trends in development and manufacturing in the biopharma industry
Klaus Graumann, Phoenestra, Austria
  Session 2 - Trends in Process Chromatography and Integrated Manufacturing
Chairman: Alexander Faude
10:00 Process considerations for development of multi-column continuous capture of monoclonal antibodies
Robert Mierendorf, Semba Biosciences, USA
10:30 Coffee break
11:00 Critical quality attributes in continuous Protein A chromatography
Patrick Endres, Tosoh Bioscience, Germany
11:30 Custom Protein A resin design and purification for column-free mAb capture - increased productivity with Continuous Countercurrent Tangential Chromatography (CCTC)
Amar Joshi, Lonza Biologics, United Kingdom
12:30 Networking Event
19:30 Dinner

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Day 3 - Wednesday, February 20
9:00 Keynote - Chairman: Cristina Dias-Cabral
TBD
Stefan Hepbildikler, Roche, Germany
  Session 3 - Antibody constructs
Chairman: Cristina Dias-Cabral
10:00 FcyRIIIA immobilized resin for glycoform- and efficacy-based separation of therapeutic antibodies
Toru Tanaka, Tosoh Corporation, Japan ^
10:30 Coffee break
11:00 Principles of applications of large particle chromatography using advanced materials
Alexei Voloshin, 3M, United States
11:30 Monoclonal antibody aggregate removal using novel POROS HIC resins
John Li, Thermo Fisher Scientific, United States
12:00 Preparation and purification of protein-mimetic drug conjugates with pH tunable hydrophobicity of the payloads
Egbert Müller, Tosoh Bioscience, Germany
12:30 Lunch
  Session 4 - DSP method development and mechanistic understanding of bioprocesses
Chairman: Shekar Grade
14:00 Assessing prediction uncertainty of mechanistic chromatography models
Till Briskot, Karlsruhe Institute of Technology, Germany
14:30 Hindered diffusion of proteins in multicomponent adsorption on porous anion exchangers
Rainer Hahn, BOKU, Austria
15:00 Coffee break
15:30 Academic Poster Flash Presentations chaired by Todd Przybycien
16:00 Podium discussion hosted by Ron Bates, Jürgen Hubbuch, and Arne Staby
17:00 Poster Apero
18:30 Dinner

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Day 4 - Thursday, February 21
  Session 5 - Hydrophobic separations and multimodal chromatography
Chairman: Egbert Müller
9:00 Resin hydrophobicity - dealing with changes in resin properties in a manufacturing environment
Ves Lesins, Bristol-Myers Squibb, United States
9:30 Binding capacity and dual salt systems in Hydrophobic Interaction Chromatography
Beate Beyer, Austrian Centre of Industrial Biotechnology, Austria
10:00 Characterization of heterogenic species obtained from oxidation and proteolysis of monoclonal antibodies using hydrophobic interaction chromatography
Atis Chakrabarti, Tosoh Bioscience, United States
10:30 Coffee break
11:00 Product-agnostic orthogonality in preparative chromatography: toward selecting and designing optimally orthogonal resins
Camille Bilodeau, Rensselaer Polytechnic Institute, United States
11:30 Using additives to improve the binding and recovery of target protein molecules in mixed-mode chromatography
Xuemei He, Bio-Rad Labs, United States
12:00 Closing remarks

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HIC/DSP Bioseparation Conference